Established in Milan, EPO Srl is a family company, specialized in the production of high quality botanical extracts since 1933. The extracts are suitable for the food (food and food supplements), pharmaceutical, feed and cosmetic industries; they are also used in the textile and detergent industry, as well as in agriculture.
EPO is the Italian acronym of “Estratti Piante Officinali” that means extracts made from medicinal plants.
The company, which is still based in Milan, has modern production facilities and a GMP-certified pharmaceutical department in Fizzonasco di Pieve Emanuele (MI), in the southern part of Milan, an area characterized by an agricultural vocation, where the food supply chain is strongly present.
NUTRACEUTICAL AND FOODExtracts for food supplements, covering 14 health areas; extractsfor drinks, functional foods, sweets, chocolate, and dairy products
PHARMACEUTICAL AND COSMETICExtracts as APIs, extracts for medical devicesand for cosmetic applications
FEEDExtracts for feed and additives
AGRICULTUREExtracts used as natural insecticides and biostimulants
TEXTILEExtracts used as natural dyes and for textile finishing
CLEANSINGExtracts for natural detergents for the environment and personal hygiene
Let prostate problems fly away... with the right ingredient!
What is it? ENOTprost is the new extract of Epilobium angustifolium L. standardized to contain 15% Oenothein B, one of the most active compounds of this plant!
The botanical species is certified by the DNA barcoding analysis.
Why should I use it? Its effects are prostate-specific: anti-inflammatory and antioxidant! The inflammation and oxidative stress should be fought and controlled as they are risk factors for the development and cronicity of prostatic problems: the most common is the inflammation (prostatitis), as well as the benign prostatic hyperplasia (BPH) and cancer (prostatic adenocarcinoma).
Who can use it? Subjects with higher risk are men aged 50 and over, although prostatitis can also affect young people, especially sportsmen and cyclists.
How to get it? Ask for a sample and click here to learn more about efficacy studies!
The Covid-19 world emergency is leading to an increase of the botanicals’ demand. However, at present, there are no scientific evidences proving the direct activity of botanicals, vitamins and, in general, of food supplements, against coronavirus SARS-CoV-2 infection. Therefore, it is strictly necessary to give proper information when advising products with unproven uses. This monograph is a state-of-the-art overview about the relationship between nutraceuticals and the alteration of some physiological conditions, to sustain psycho-physical health and to boost resiliency.
*Our body always tries to respond to infections; however, sometimes the body could overreact. It is well known that when SARS -CoV-2 enters the lungs, it triggers an immune response, but, in some patients, excessive levels of cytokines are released, resulting in a hyperinflammation, that may eventually kill the patient. Cytokine storm is a common complication of many respiratory diseases, with infectious-origin or not. Healthy people already using food supplements for boosting the immune system could continue doing it; however, it is unknown what happens in case of acute infection and cytokine storm. It is important to highlight that ongoing clinical trials are not using immunostimulant therapies.
Botanical extracts to sustain psycho-physical health
Plants and botanical extracts are extensively known for their long traditional uses on many physiological pathways. They are used in healthy subjects to maintain their overall health and to prevent the developing of some risk factors; the functional claims of the following plants are retrieved by Annex I of the Italian Decree DM 10 August 2018 and are supported by literature data.
BLACK ELDER: it has expectorant and diaphoretic properties. It is traditionally known for the relief of common cold symptom.
DERMOGRANATE®: many studies suggest the following functional properties: vasculo-protective, reduction of oxidative stress and platelet aggregation, influence on endothelial cell function, regulation of blood pressure (attenuates hypertension and atherosclerosis in humans), regulation of lipid metabolism in metabolic disorder-associated diseases and type 2 diabetes, anti-inflammatory (reducing the cytokine storm). Moreover, ellagic acid has mitochondria protective activity.
GINSENG: it has tonic-adaptogen activity since it is used for the relief of mental stress. It is recommended in case of physical and mental fatigue. It is a good antioxidant.
HAWTHORN: its traditional use is strongly related to the enhancement of cardiovascular system functioning. In particular, it has cardio-tonic, coronary dilator, antiarrhythmic properties and regulates the blood pressure. Its flavonoids have antioxidant activity. It is also considered a nervine herb, positively acting on stress, anxiety, insomnia and mild depression.
LAVANDER: it is another important nervine herb, recommended for the relief of mild symptoms of mental stress and anxiety (it has spasmolytic properties), and as sleep aid. It is also considered a good mood enhancer.
LEMON BALM: it belongs to nervine herbs and is widely known as an antispasmodic, mild sedative, anxiolytic and nootropic plant. It is recommended for insomnia of nervous origin, for memory improvement and for the relief of mild symptoms of mental stress, and as mood enhancer. It has also antioxidant and antiviral activity.
OMEOLIPID®: it is a blend of three plants with many physiological properties: OMEOlipid acts on the metabolism of lipids (cholesterol) and carbohydrates (it is hypolipidemic, anti-cholesterolemic, hypoglycemic). It regulates the blood pressure; it is a good antioxidant and improves liver functions.
PASSION FLOWER: it is considered a nervine herb; it is traditionally used for the relief of mild symptoms of mental stress, mental fatigue and as a sleep aid in insomnia.
PURPLE CONEFLOWER: it is used for the relief of common cold and flu symptoms, thanks to its activity on immune system and anti-inflammatory properties.
THYMOX-EPO® was proved to have anti-inflammatory and expectorant activities in respiratory epithelial cells. It is used in productive cough associated with cold and bronchitis. It is balsamic, antiseptic for the throat and the respiratory system. It has also strong antioxidant activity.
Italian Decree DM 10 August 2018, EMA monographs and assessment reports, ESCOP monographs.
Campanini E. (2006) Dizionario di fitoterapia e piante medicinali II Ed. Tecniche Nuove, 1-635
Capasso F., Grandolini G., Izzo A.A., Fitoterapia, Springer-Verlag Italia; 2006.
Gruenwald J. PDR for herbal medicine, 4th Ed. Thomson, 2006.
Abascal K, Yarnell E. Nervine Herbs for Treating Anxiety. Alternative and Complementary Therapies. Dec 2004.309-315.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020 Mar 13;7(1):11.
Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses. 2020 Jan 24;12(2). pii: E135.
To read more articles specific for each plant and application please contact us.
Adaptogenic effects of herbal extracts
The term ‘adaptogen’ refers to natural compounds or plant extracts that increase adaptability and survival of organisms to stress. They exhibit anti-fatigue effects during stress and show promising potential against age-related conditions. Adaptogens stimulate cellular and organism defense systems by means:
- activating intracellular and extracellular signaling pathways and expression of stress-activated proteins and neuropeptides;
- enhancing survival against oxidative stress;
- ameliorating and postponing aging by activation of mediator genes of stress response and modulation of longevity pathways.
Scientific community is trying to identify key molecular mechanisms that are in common among more than 70 plants which have adaptogenic action, to provide a rationale for the use of adaptogens in stress- and age-related diseases, as shown in the following pictures (retrieved from Panossian et al., 2018).
Among all adaptogens, Ginseng is one of the oldest one. Etymologically, panax means ‘all-healing’ or ‘panacea’. Chinese Materia Medica documents its usage since 5,000 years ago. Pharmacopeias across Japan, Korea, USA, Canada, Germany, UK, France and Austria recognize its ability to boost vitality and wellbeing.
Ginseng adaptogenic effect is apparently a function of the ginsenoside saponin glycosides contained in the root and are linked to a corticosteroid-like action. In fact, endocrinological studies have suggested that ginsenosides may augment adrenal steroidogenesis (production of steroid hormones) via an indirect action on the pituitary gland. The hormones produced by the hypothalamus-pituitary-adrenal axis are well known to play a significant role in the adaptation capabilities of the body. In the picture the involvement of Ginseng is shown (retrieved from Nocerino et al., 2000).
General literature data:
- Nocerino E, Amato M, Izzo AA. 2000. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 71: S1-S5
- Panossian A. 2017. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Annals of the NY Acad. Science. Issue: Phytochemicals in Medicine and Food. 1401: 49–64
- Panossian A, Seoc EJ, Efferthc T. 2018. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine 50: 257–284
- Patel S. & Rauf A. 2017. Adaptogenic herb ginseng (Panax) as medical food: Status quo and future prospects. Biomedicine & Pharmacotherapy 85: 120–127
Here the right botanicals by EPO
Click on each plant to learn more…
Thyme (Thymus vulgaris L.) is a well-known Mediterranean plant, belonging to the Lamiaceae family. The thyme extract is traditionally used as natural remedy for many purposes. Therefore, download our brochure and do not miss the properties of our thyme extract!
Nature, Tradition and Science serving beauty!
we have selected some extracts to help you to formulate a food supplement for skin care! Botanicals have always been a perfect adjuvant for the beauty of the skin and body.
Download here a short monograph and do not hesitate to contact us for more information.