Fondata a Milano nel 1933, EPO Srl è una storica azienda familiare, specializzata nella produzione di estratti vegetali di elevata qualità, per il settore alimentare (alimenti ed integratori alimentari), farmaceutico, veterinario e cosmetico. Gli estratti trovano inoltre impiego nel settore tessile e della detergenza, così come in agricoltura.
L’acronimo EPO significa: “Estratti Piante Officinali”.
L’azienda, che ha tutt’ora sede a Milano, dispone di modernissimi impianti produttivi e di un reparto farmaceutico certificato GMP, situati in Fizzonasco di Pieve Emanuele (MI), nella zona meridionale dell’hinterland milanese, un’area da sempre a forte vocazione agricola, dove la filiera alimentare è fortemente presente.
NUTRACEUTICO ED ALIMENTAREEstratti per integratori alimentari, che coprono ben 14 aree salutistiche; inoltre estrattiper bevande, cibi funzionali, caramelle, cioccolato, dolciumi e latticini.
FARMACEUTICO E COSMETICOEstratti registrati come API, estratti per dispositivi medici e per applicazioni cosmetiche.
VETERINARIOEstratti per mangimi ed additivi.
AGRICOLOEstratti da impiegarsi come insetticidi naturali e biostimolanti.
TESSILEEstratti da impiegarsi come coloranti naturali e per il finissaggio tessile.
DETERGENZAEstratti per detergenti naturali destinati all’igiene degli ambienti e della persona.
Con l\'estratto giusto i problemi di prostata volano via!
Cos\'è: ENOTprost è il nuovo estratto di Epilobium angustifolium L. con il 15% di Enoteina B, una delle molecole più attive di questa pianta!
La specie botanica è certificata tramite l\'analisi DNA barcoding.
Perché si usa: I suoi effetti sono specifici per il benessere della prostata: anti-infiammatorio e antiossidante! L\'infiammazione e lo stress ossidativo vanno combattuti e controllati in quanto sono fattori di rischio e di cronicità dei problemi alla prostata: il più comune è l\'infiammazione (prostatite), ma anche l\'ipertrofia prostatica benigna (IPB) ed il tumore (adenocarcinoma prostatico).
Chi lo può usare: I soggetti maggiormente a rischio sono gli uomini dai 50 anni in su, seppur le prostatiti possono colpire anche in età giovanile, sopratutto gli sportivi ed in particolare i ciclisti.
Come procedere: Richiedi un campione al nostro reparto commerciale e clicca qui per approfondire gli studi di efficacia
Clicca qui per avere maggiori dettagli sul progetto
COVID 19: WHAT ABOUT PHYTOTHERAPY?
The Covid-19 world emergency is leading to an increase of the botanicals’ demand. However, at present, there are no scientific evidences proving the direct activity of botanicals, vitamins and, in general, of food supplements, against coronavirus SARS-CoV-2 infection. Therefore, it is strictly necessary to give proper information when advising products with unproven uses. This monograph is a state-of-the-art overview about the relationship between nutraceuticals and the alteration of some physiological conditions, to sustain psycho-physical health and to boost resiliency.
*Our body always tries to respond to infections; however, sometimes the body could overreact. It is well known that when SARS -CoV-2 enters the lungs, it triggers an immune response, but, in some patients, excessive levels of cytokines are released, resulting in a hyperinflammation, that may eventually kill the patient. Cytokine storm is a common complication of many respiratory diseases, with infectious-origin or not. Healthy people already using food supplements for boosting the immune system could continue doing it; however, it is unknown what happens in case of acute infection and cytokine storm. It is important to highlight that ongoing clinical trials are not using immunostimulant therapies.
Botanical extracts to sustain psycho-physical health
Plants and botanical extracts are extensively known for their long traditional uses on many physiological pathways. They are used in healthy subjects to maintain their overall health and to prevent the developing of some risk factors; the functional claims of the following plants are retrieved by Annex I of the Italian Decree DM 10 August 2018 and are supported by literature data.
BLACK ELDER: it has expectorant and diaphoretic properties. It is traditionally known for the relief of common cold symptom.
DERMOGRANATE®: many studies suggest the following functional properties: vasculo-protective, reduction of oxidative stress and platelet aggregation, influence on endothelial cell function, regulation of blood pressure (attenuates hypertension and atherosclerosis in humans), regulation of lipid metabolism in metabolic disorder-associated diseases and type 2 diabetes, anti-inflammatory (reducing the cytokine storm). Moreover, ellagic acid has mitochondria protective activity.
GINSENG: it has tonic-adaptogen activity since it is used for the relief of mental stress. It is recommended in case of physical and mental fatigue. It is a good antioxidant.
HAWTHORN: its traditional use is strongly related to the enhancement of cardiovascular system functioning. In particular, it has cardio-tonic, coronary dilator, antiarrhythmic properties and regulates the blood pressure. Its flavonoids have antioxidant activity. It is also considered a nervine herb, positively acting on stress, anxiety, insomnia and mild depression.
LAVANDER: it is another important nervine herb, recommended for the relief of mild symptoms of mental stress and anxiety (it has spasmolytic properties), and as sleep aid. It is also considered a good mood enhancer.
LEMON BALM: it belongs to nervine herbs and is widely known as an antispasmodic, mild sedative, anxiolytic and nootropic plant. It is recommended for insomnia of nervous origin, for memory improvement and for the relief of mild symptoms of mental stress, and as mood enhancer. It has also antioxidant and antiviral activity.
OMEOLIPID®: it is a blend of three plants with many physiological properties: OMEOlipid acts on the metabolism of lipids (cholesterol) and carbohydrates (it is hypolipidemic, anti-cholesterolemic, hypoglycemic). It regulates the blood pressure; it is a good antioxidant and improves liver functions.
PASSION FLOWER: it is considered a nervine herb; it is traditionally used for the relief of mild symptoms of mental stress, mental fatigue and as a sleep aid in insomnia.
PURPLE CONEFLOWER: it is used for the relief of common cold and flu symptoms, thanks to its activity on immune system and anti-inflammatory properties.
THYMOX-EPO® was proved to have anti-inflammatory and expectorant activities in respiratory epithelial cells. It is used in productive cough associated with cold and bronchitis. It is balsamic, antiseptic for the throat and the respiratory system. It has also strong antioxidant activity.
Italian Decree DM 10 August 2018, EMA monographs and assessment reports, ESCOP monographs.
Campanini E. (2006) Dizionario di fitoterapia e piante medicinali II Ed. Tecniche Nuove, 1-635
Capasso F., Grandolini G., Izzo A.A., Fitoterapia, Springer-Verlag Italia; 2006.
Gruenwald J. PDR for herbal medicine, 4th Ed. Thomson, 2006.
Abascal K, Yarnell E. Nervine Herbs for Treating Anxiety. Alternative and Complementary Therapies. Dec 2004.309-315.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020 Mar 13;7(1):11.
Gralinski LE, Menachery VD. Return of the Coronavirus: 2019-nCoV. Viruses. 2020 Jan 24;12(2). pii: E135.
To read more articles specific for each plant and application please contact us.
Ecco la selezione di estratti EPO di elevata qualità, sicurezza ed efficacia
Clicca su ogni pianta per saperne di più…
Il Timo volgare
La Piantaggine lanceolata
Adaptogenic effects of herbal extracts
The term ‘adaptogen’ refers to natural compounds or plant extracts that increase adaptability and survival of organisms to stress. They exhibit anti-fatigue effects during stress and show promising potential against age-related conditions. Adaptogens stimulate cellular and organism defense systems by means:
- activating intracellular and extracellular signaling pathways and expression of stress-activated proteins and neuropeptides;
- enhancing survival against oxidative stress;
- ameliorating and postponing aging by activation of mediator genes of stress response and modulation of longevity pathways.
Scientific community is trying to identify key molecular mechanisms that are in common among more than 70 plants which have adaptogenic action, to provide a rationale for the use of adaptogens in stress- and age-related diseases, as shown in the following pictures (retrieved from Panossian et al., 2018).
Among all adaptogens, Ginseng is one of the oldest one. Etymologically, panax means ‘all-healing’ or ‘panacea’. Chinese Materia Medica documents its usage since 5,000 years ago. Pharmacopeias across Japan, Korea, USA, Canada, Germany, UK, France and Austria recognize its ability to boost vitality and wellbeing.
Ginseng adaptogenic effect is apparently a function of the ginsenoside saponin glycosides contained in the root and are linked to a corticosteroid-like action. In fact, endocrinological studies have suggested that ginsenosides may augment adrenal steroidogenesis (production of steroid hormones) via an indirect action on the pituitary gland. The hormones produced by the hypothalamus-pituitary-adrenal axis are well known to play a significant role in the adaptation capabilities of the body. In the picture the involvement of Ginseng is shown (retrieved from Nocerino et al., 2000).
General literature data:
- Nocerino E, Amato M, Izzo AA. 2000. The aphrodisiac and adaptogenic properties of ginseng. Fitoterapia 71: S1-S5
- Panossian A. 2017. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Annals of the NY Acad. Science. Issue: Phytochemicals in Medicine and Food. 1401: 49–64
- Panossian A, Seoc EJ, Efferthc T. 2018. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine 50: 257–284
- Patel S. & Rauf A. 2017. Adaptogenic herb ginseng (Panax) as medical food: Status quo and future prospects. Biomedicine & Pharmacotherapy 85: 120–127
CINNAMON IS NOT ONLY A SPICE!
Cinnamon is one of the oldest known herbs: obtained from an exotic tree, indigenous to Sri Lanka and Southwest India, it is mentioned in the Bible as well as in Sanskrit, Egyptian, Greek and Roman texts. Its inner bark, after drying and curling into rolls known as “sticks” or “quills”, is mainly used as a spice, especially in Christmas cookies, herbal teas and other winter comfort foods or delicacies. Nevertheless, Cinnamon can claim a very long traditional use, as a tonic, carminative, spasmolytic, eupeptic and antiseptic agent; in Ayurvedic medicine Cinnamon is a major digestive herb, but it is also said to improve circulation, nocturia, arthritis, male impotency and cardiac insufficiency. In recent times the plant has attracted much interest for its ability to lower serum lipids and blood glucose: in a meta-analysis the consumption of Cinnamon was associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C, triglycerides levels and an increase of HDL-C levels, while in a recent randomized, placebo controlled clinical trial the intake of 1 g Cinnamon powder for 12 weeks reduced fasting blood glucose and glycosylated Hb among poorly controlled type 2 diabetes patients.
Those benefits have been attributed to cinnamaldehyde and to the polyphenolic fraction, some natural, powerful antioxidants and radical scavengers.
ARE YOU SURE THAT YOU ARE USING THE RIGHT CINNAMON?
The name ‘Cinnamon’ is correctly used to refer to Ceylon Cinnamon, also known as ‘True Cinnamon’ (Cinnamomum verum J. Presl). Despite this, other species are sometimes sold as Cinnamon, i.e. Chinese Cinnamon (Cinnamomum cassia (Nees & T.Nees) J.Presl). The True Cinnamon is considered totally safe, while there is a concern about the Chinese one, especially in case of prolonged use, due to its coumarin content; Chinese Cinnamon is a cheaper alternative to the true spice coming from Sri Lanka and recent studies have proved that most of the Cinnamon powder on the food market is mislabeled and comes from Chinese Cinnamon.
EPO SRL is now launching a Cinnamon extract for the food market, whose botanical species is certified through DNA barcoding test, a technique for characterizing species using a short DNA sequence from a standard part of the genome; the technique is similar to a supermarket scanner, which identifies products by reading black bars of the UPC (Universal Product Code): the sample is identified by finding the closest matching between its isolated DNA sequence and a reference sequence of an official barcode database.
EPO’s True Cinnamon Dry Extract, standardised to contain 25-30% polyphenols, associates the taste and flavour of the powdered spice with safety and health benefits, especially in cardiovascular protection and glycemia control, of a concentrated source, such as an extract.
This work was presented at \'Pharmacology 2019 Congress\' in Edinburgh
Download here the \'book of abstract\'